【研究發展處訊】

微生物學系楊鉅文教授發表新冠肺炎病毒基因密碼相關之最新期刊論文

Composition of Human-Specific Slow Codons and Slow Di-Codons in SARS-CoV and 2019-nCoV Are Lower Than Other Coronaviruses Suggesting a Faster Protein Synthesis Rate of SARS-CoV and 2019-nCoV

作者：Chu-Wen Yang, Mei-Fang Chen

Journal of Microbiology, Immunology and Infection (SCI)

卷：53  期：2

頁碼：頁419-424

出版日期：Jun. 2020

摘要：

本論文探討新冠肺炎病毒基因密碼組成可能與病毒在人類細胞中快速複製有關。

Translation of a genetic codon without a cognate tRNA gene is affected by both the cognate tRNA availability and the interaction with non-cognate isoacceptor tRNAs. Moreover, two consecutive slow codons (slow di-codons) lead to a much slower translation rate. Calculating the composition of host specific slow codons and slow di-codons in the viral protein coding sequences can predict the order of viral protein synthesis rates between different virus strains. Comparison of human-specific slow codon and slow di-codon compositions in the genomes of 590 coronaviruses infect humans revealed that the protein synthetic rates of 2019 novel coronavirus (2019-nCoV) and severe acute respiratory syndrome-related coronavirus (SARS-CoV) may be much faster than other coronaviruses infect humans. Analysis of host-specific slow codon and di-codon compositions provides links between viral genomic sequences and capability of virus replication in host cells that may be useful for surveillance of the transmission potential of novel viruses.

文章網頁連結: https://www.sciencedirect.com/science/article/pii/S1684118220300591?via%3Dihub

研究事務組小提醒：教師如有最新發表於AHCI、SSCI、SCI、EI、TSSCI、THCI、「東吳大學外語學門獎勵名單」之期刊論文，歡迎將相關資訊e-mail至rad@scu.edu.tw，研究發展處將會公告於校園頭條，以廣交流。

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