【研究發展處訊】
化學系江建緯助理教授發表最新期刊論文
Promotion of S-nitrosation of cysteine by a {Co(NO)2}10 complex
作者:Chien-Wei Chiang, Kai-Wun Jhang, Jeng-Lung Chen, Liang-Ching Hsu, Wei-Hsiang Huang, Hung-Chi Chen, Ting-Jun Lin, Ci-Yang Sun and Yu-Ning Li
Chemical Communications (SCI)
Early Access:JUL 2023
DOI:10.1039/d3cc02784h
摘要:
S-Nitrosothiols (SNOs) serve as endogenous carriers and donors of NO within living cells, releasing nitrosonium ions (NO+), NO, or other nitroso derivatives. In this study, we present a bioinspired {Co(NO)2}10 complex 1 that achieved S-nitrosation towards Cys residues. The incorporation of a ferrocenyl group in 1 allowed for fine-tuning of the nitrosation reaction, taking advantage of the redox ability of Cys residues. Complex 1 was synthesized and characterized, demonstrating its NO translation reactivity. Furthermore, complex 1 successfully converted Cys into S-nitrosocysteine (Cys-SNO), as confirmed by UV-Vis, IR, and XAS spectroscopy. This study presents a promising approach for S-nitrosation of Cys residues for further exploration in the modification of Cys-containing peptides.
研究事務組提醒:教師如有最新發表於AHCI、SSCI、SCI、EI、TSSCI、THCI、「東吳大學外語學門獎勵名單」之期刊論文,歡迎將相關資訊e-mail至rad@scu.edu.tw,研究發展處將會公告於校園頭條,以廣交流。
【文圖/研究事務組謝明秀專員】
類別 | 標題 | 登刊日期 |
校園頭條 | 「韌齡心北投生活圈」USR計畫 參展2025大學社會責任實踐博覽會 | 09/05/2025 |
校園頭條 | 按下青春啟動鍵 第1哩新生定向活動迎接東吳新鮮人 | 09/04/2025 |
校園頭條 | 企管系師生赴越南河內展開14天企業參訪與見習 | 09/03/2025 |
校園頭條 | 修練由聲到心的五大超能力 東吳「聲音魔法學苑」開課 | 09/01/2025 |
校園頭條 | 「VR實驗室安全系統」首度亮相 教育部專班引領數位安全教育新里程碑 | 08/29/2025 |