【研究發展處訊】
化學系江建緯助理教授發表最新期刊論文
Promotion of S-nitrosation of cysteine by a {Co(NO)2}10 complex
作者:Chien-Wei Chiang, Kai-Wun Jhang, Jeng-Lung Chen, Liang-Ching Hsu, Wei-Hsiang Huang, Hung-Chi Chen, Ting-Jun Lin, Ci-Yang Sun and Yu-Ning Li
Chemical Communications (SCI)
Early Access:JUL 2023
DOI:10.1039/d3cc02784h
摘要:
S-Nitrosothiols (SNOs) serve as endogenous carriers and donors of NO within living cells, releasing nitrosonium ions (NO+), NO, or other nitroso derivatives. In this study, we present a bioinspired {Co(NO)2}10 complex 1 that achieved S-nitrosation towards Cys residues. The incorporation of a ferrocenyl group in 1 allowed for fine-tuning of the nitrosation reaction, taking advantage of the redox ability of Cys residues. Complex 1 was synthesized and characterized, demonstrating its NO translation reactivity. Furthermore, complex 1 successfully converted Cys into S-nitrosocysteine (Cys-SNO), as confirmed by UV-Vis, IR, and XAS spectroscopy. This study presents a promising approach for S-nitrosation of Cys residues for further exploration in the modification of Cys-containing peptides.
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