【研究發展處訊】

微生物學系楊鉅文教授發表新冠肺炎病毒相關之最新期刊論文

Uncovering potential host proteins and pathways that may interact with eukaryotic short linear motifs in viral proteins of MERS, SARS and SARS2 coronaviruses that infect humans

作者：Chu-Wen Yang, Zhi-Ling Shi

PLoS ONE (SCI)

卷數：16

期數：2

文獻號碼：e0246150

出版日期：Feb 2021

摘要：

A coronavirus pandemic caused by a novel coronavirus (SARS-CoV-2) has spread rapidly worldwide since December 2019. Improved understanding and new strategies to cope with novel coronaviruses are urgently needed. Viruses (especially RNA viruses) encode a limited number and size (length of polypeptide chain) of viral proteins and must interact with the host cell components to control (hijack) the host cell machinery. To achieve this goal, the extensive mimicry of SLiMs in host proteins provides an effective strategy. However, little is known regarding SLiMs in coronavirus proteins and their potential targets in host cells. The objective of this study is to uncover SLiMs in coronavirus proteins that are present within host cells. These SLiMs have a high possibility of interacting with host intracellular proteins and hijacking the host cell machinery for virus replication and dissemination. In total, 1,479 SLiM hits were identified in the 16 proteins of 590 coronaviruses infecting humans. Overall, 106 host proteins were identified that may interact with SLiMs in 16 coronavirus proteins. These SLiM-interacting proteins are composed of many intracellular key regulators, such as receptors, transcription factors and kinases, and may have important contributions to virus replication, immune evasion and viral pathogenesis. A total of 209 pathways containing proteins that may interact with SLiMs in coronavirus proteins were identified. This study uncovers potential mechanisms by which coronaviruses hijack the host cell machinery. These results provide potential therapeutic targets for viral infections.

本論文比較新冠肺炎病毒與普通冠狀病毒蛋白質功能區段組成的差異，探討不同病毒對宿主細胞影響不同。本文是東吳第二篇新冠病毒的研究論文。

文章網頁連結:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0246150

研究事務組小提醒：教師如有最新發表於AHCI、SSCI、SCI、EI、TSSCI、THCI、「東吳大學外語學門獎勵名單」之期刊論文，歡迎將相關資訊e-mail至rad@scu.edu.tw，研究發展處將會公告於校園頭條，以廣交流。

【文圖/研究事務組游晴如組員】